Readers ask: What Antibiotic Is Deactivated By Surfactant?


How does surfactant inhibit daptomycin?

The inhibition of daptomycin by pulmonary surfactant is directly related to its novel mechanism of action: calcium-dependent insertion into the bacterial membrane. Insertion of daptomycin into surfactant aggregates in vitro could be demonstrated by means of a fluorescence assay (Figure 1B).

Why can you use daptomycin in pneumonia?

Daptomycin should not be used to treat pneumonia. This is due to the fact that daptomycin is inhibited by surfactant (Silverman et al 2005).

When is daptomycin used?

Daptomycin is an antibiotic that is used to treat bacterial infections of the skin and underlying tissues, and infections that have entered the bloodstream. Daptomycin is used for complicated infections, including MRSA or “super bug” infections.

How does daptomycin work?

Daptomycin injection is used to treat certain blood infections or serious skin infections caused by bacteria in adults and children 1 year of age and older. Daptomycin injection is in a class of medications called cyclic lipopeptide antibiotics. It works by killing bacteria.

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Is a surfactant?

Surfactant, also called surface-active agent, substance such as a detergent that, when added to a liquid, reduces its surface tension, thereby increasing its spreading and wetting properties. Other surfactant molecules clump together into smaller aggregates called micelles, which also absorb monomer molecules.

How do surfactants work in lungs?

It is established that pulmonary surfactant reduces surface tension at the air–water interface in the alveoli, thereby preventing collapse of these structures at end-expiration. In this manner, surfactant reduces the work associated with breathing.

Which antibiotics are effective against VRE?

Linezolid, daptomycin, tigecycline, oritavancin, telavancin, quinupristin-dalfopristin and teicoplanin (not available in the U.S.) are antimicrobials that have been used with success against various VRE strains. Clinicians have also had some success in treating VRE with various combinations of antibiotics.

Is daptomycin the same as vancomycin?

Daptomycin, a lipopeptide antibiotic, is approved by the US Food and Drug Administration for the treatment of S. aureus bacteremia and is considered a reasonable alternative to vancomycin. The efficacy of daptomycin has been demonstrated in an open-label randomized clinical trial by Fowler et al.

What antibiotic is good for gram-negative rods?

Fourth-generation cephalosporins such as cefepime, extended-spectrum β-lactamase inhibitor penicillins (piperacillin/tazobactam, ticarcillin/clavulanate) and most importantly the carbapenems (imipenem/cilastatin, meropenem, ertapenem) provide important tools in killing Gram – negative infections.

Is daptomycin hard on the kidneys?

Statistical analysis. In a previous study [17], the incidence of renal dysfunction was estimated at 12% with daptomycin and 35% with standard therapy. However, a higher incidence of renal failure was expected in ICU population, as much as twice the incidence observed in the reference study [10, 19].

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How much does daptomycin cost?

The cost for daptomycin intravenous powder for injection 500 mg is around $31 for a supply of 1 powder for injection, depending on the pharmacy you visit. Intravenous Powder For Injection.

Quantity Per unit Price
1 $26.71 – $242.18 $26.71 – $242.18
10 $45.90 – $233.63 $458.96 – $2,336.30

What is another name for daptomycin?

Cubicin ( daptomycin ) is an antibiotic used to treat bacterial infections of the skin and underlying tissues.

When should you not take daptomycin?

Daptomycin should be discontinued in patients with symptoms of muscle pain or weakness whose CPK levels exceed 1000 U/L (~ 5x ULN), or in patients without symptoms whose CPK exceeds 10x ULN.

What should I monitor while on daptomycin?

Therefore weekly monitoring of creatine phosphokinase (CPK) levels is recommended in patients receiving daptomycin therapy. More frequent monitoring is recommended in patients with renal impairment and/or those receiving concomitant HMG CoA reductase inhibitors (statins).

Can daptomycin be given IV push?

In paediatric patients aged 7 to 17 years, Daptomycin is given by intravenous infusion over a 30-minute period (see section 6.6). In paediatric patients aged 2 to 6 years, Daptomycin is given by intravenous infusion over a 60-minute period (see section 6.6).

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