Readers ask: Of The Antibiotic Listed Below Which Does Not Inhibiting Bacterial Protein Synthesis?


Which antibiotic does not inhibit protein synthesis?

Lincomycin and clindamycin are specific inhibitors of peptidyl transferase, while macrolides do not directly inhibit the enzyme.

Which antibiotics inhibit protein synthesis?

Antibiotics can inhibit protein synthesis by targeting either the 30S subunit, examples of which include spectinomycin, tetracycline, and the aminoglycosides kanamycin and streptomycin, or to the 50S subunit, examples of which include clindamycin, chloramphenicol, linezolid, and the macrolides erythromycin,

Which of the following antibiotics target bacterial protein synthesis?

Two common antibiotics were chosen: (1), gentamicin, a broad spectrum antibiotic aminoglycoside, which is a class of drugs that binds to the 30 S subunit of ribosomes thus preventing bacterial protein synthesis [33] and (2) polymyxin B, a cyclic cationic polypeptide, which is commonly used against Gram-negative

Do penicillins inhibit protein synthesis?

No harm comes to the human host because penicillin does not inhibit any biochemical process that goes on within us. Bacteria can also be selectively eradicated by targeting their metabolic pathways.

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Are examples of drugs that inhibit protein synthesis?

The following are the medications that are protein synthesis inhibitors.

  • Aminoglycosides.
  • Tetracycline and glycylcycline.
  • Oxazolidinones.
  • Amphenicols and pleuromutilins.
  • Macrolides and ketolides.
  • Lincosamides.
  • Streptogramins.

Do antibiotics disrupt protein synthesis?

Antibiotics that bind the A-site, such as the aminoglycosides, interfere with codon recognition and translocation. Peptide bond formation is inhibited when small molecules like oxazolidinones bind at the PTC. Finally, macrolides tend to block the growth of the amino acid chain at the peptide exit tunnel.

What stops protein synthesis?

Nonsense suppression occurs when a stop (or nonsense) codon of mRNA (UAA, UAG or UGA) is decoded by the translation machinery as an amino acid, rather than eliciting termination of protein synthesis.

Can viruses be killed by inhibiting their protein synthesis?

As a general rule, maximal inhibition of host-cell protein synthesis occurs with viruses that eventually kill their host-cell during the later phases of infection, when viral coat protein is being made in large amounts.

How do antibiotics affect translation?

The ribosome is a major bacterial target for antibiotics. Drugs inhibit ribosome function either by interfering in messenger RNA translation or by blocking the formation of peptide bonds at the peptidyl transferase centre.

What is bacterial protein synthesis?

The synthesis of proteins in bacteria is essentially a two-stage process involving transcription (the synthesis of a messenger RNA (mRNA) intermediate using one strand of the duplex DNA as the template) and translation (the decoding of the information in the mRNA into an ordered arrangement of amino acids to form a

How does protein synthesis in bacteria work?

Bacterial species typically have between 60 and 90 types. Serving as adaptors, each tRNA type binds to a specific codon on the mRNA template and adds the corresponding amino acid to the polypeptide chain. Therefore, tRNAs are the molecules that actually “translate” the language of RNA into the language of proteins.

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Is amoxicillin a reversible or irreversible inhibitor?

For diphenolase activity, amoxicillin was found to be a reversible inhibitor, with an IC50 value of 9.0 ± 1.8 mM. Kinetics analysis showed that amoxicillin was a mixed type inhibitor of the enzyme with KI and KIS values of 8.30 mM and 44.79 mM, respectively.

What antibiotic is a cell wall inhibitor?

Penicillins and cephalosporins are the major antibiotics that inhibit bacterial cell wall synthesis. They are called beta-lactams because of the unusual 4-member ring that is common to all their members.

What are the five main classes of antimicrobial drugs?

Antimicrobial agents are classified into several categories, i.e. inhibitors for bacterial cell wall such as beta-lactam drugs, fosfomycin, and vancomycin; inhibitors for protein biosynthesis such as tetracyclibnes, macrolides, aminoglycoside antibiotics; inhibitors for DNA synthesis such as 4-quinolones; inhibitors

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