- 1 What bacteria does isoniazid treat?
- 2 Is isoniazid a broad spectrum antibiotic?
- 3 How does isoniazid stop the growth of bacteria?
- 4 What is the best time to take isoniazid?
- 5 Which is a serious side effect of isoniazid?
- 6 Why is isoniazid H?
- 7 Can isoniazid cause hair loss?
- 8 What is the target of isoniazid?
- 9 Does isoniazid make you gain weight?
- 10 Can I drink coffee while taking isoniazid?
- 11 Why can’t antibiotics treat viruses?
- 12 What vitamins should I take with isoniazid?
- 13 Does isoniazid cause liver damage?
- 14 How do I reduce the side effects of isoniazid?
What bacteria does isoniazid treat?
Isoniazid ( INH ) was the first synthesized drug that mediated bactericidal killing of the bacterium Mycobacterium tuberculosis, a major clinical breakthrough. To this day, INH remains a cornerstone of modern tuberculosis (TB) chemotherapy.
Is isoniazid a broad spectrum antibiotic?
40,41 Three of the four first-line anti-TB drugs are narrow- spectrum, isoniazid 1, pyrazinamide 2, and ethambutol 3 (Fig. 1), having little or no activity outside the mycobacterial genus.
How does isoniazid stop the growth of bacteria?
It works by killing the bacteria that cause the disease. The exact mechanism of action of isoniazid is unknown, but it is thought to prevent the tuberculosis bacteria from making substances called mycolic acids, which are needed to form the cell walls of the bacteria.
What is the best time to take isoniazid?
Take isoniazid on an empty stomach, at least 1 hour before or 2 hours after a meal. Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics.
Which is a serious side effect of isoniazid?
Tell your doctor right away if any of these rare but serious side effects occur: increased thirst/urination, vision changes, easy bruising/bleeding, mental/mood changes (such as confusion, psychosis), seizures. A very serious allergic reaction to this drug is rare.
Why is isoniazid H?
Isoniazid, also known as isonicotinic acid hydrazide ( INH ), is an antibiotic used for the treatment of tuberculosis. Isoniazid.
|Protein binding||Very low (0–10%)|
|Metabolism||liver; CYP450: 2C19, 3A4 inhibitor|
|Elimination half-life||0.5–1.6 h (fast acetylators), 2-5h (slow acetylators)|
|Excretion||urine (primarily), feces|
Can isoniazid cause hair loss?
Isoniazid is a safe and very effective antituberculosis drug. Antimitotic agents routinely cause alopecia. Drug- induced alopecia is usually reversible upon withdrawal of the drug. Isoniazid, thiacetazone and ethionamide are the antituberculosis drugs which have been associated with alopecia.
What is the target of isoniazid?
The primary target of isoniazid is believed to be InhA, a NADH-dependent enoyl acyl carrier protein reductase involved in the synthesis of mycolic acid. The activated species, presumably an isonicotinic acyl radical, forms an adduct with the NAD radical.
Does isoniazid make you gain weight?
In man, Faloon (1953) found no change in nitrogen balance, appetite, or food intake in three patients with non- tuberculous disease given isoniazid for six to eight days. The observations here presented provide no evidence that isoniazid has any effect in causing gain in weight in the normal human male.
Can I drink coffee while taking isoniazid?
Notes for Consumers: Try to limit caffeine intake while taking Isoniazid, INH. Side effects from Isoniazid, INH may get worse if you take Caffeine, like increased blood pressure, confusion, restlessness, or other side effects.
Why can’t antibiotics treat viruses?
Viruses don’t have cell walls that can be attacked by antibiotics; instead they are surrounded by a protective protein coat. Unlike bacteria, which attack your body’s cells from the outside, viruses actually move into, live in and make copies of themselves in your body’s cells.
What vitamins should I take with isoniazid?
Vitamin B6 (pyridoxine) supplementation during isoniazid ( INH ) therapy is necessary in some patients to prevent the development of peripheral neuropathy.
Does isoniazid cause liver damage?
Isoniazid ( INH ) remains a mainstay for the treatment of tuberculosis despite the fact that it can cause liver failure.
How do I reduce the side effects of isoniazid?
It is important that you do not miss any doses. Your doctor may also want you to take pyridoxine (e.g., Hexa-Betalin, vitamin B 6) every day to help prevent or lessen some of the side effects of isoniazid.