- 1 Which lab test is to be monitored while the client is on treatment with aminoglycosides?
- 2 What labs should be monitored with gentamicin?
- 3 Which labs should be monitored before and during the antibiotic therapy?
- 4 Which condition would the nurse monitor for in a patient who is taking an aminoglycoside antibiotic quizlet?
- 5 What drugs require therapeutic monitoring?
- 6 What are the factors controlling therapeutic drug monitoring?
- 7 What trough level would be considered a normal concentration?
- 8 What are two serious side effects of gentamicin or tobramycin?
- 9 What is a peak and trough level?
- 10 Why do some drugs need to have their blood levels monitored?
- 11 How do you do Therapeutic Drug Monitoring?
- 12 Which antibiotics require therapeutic monitoring?
- 13 Which antibiotic is used in patients who have infections of the eyes ears or skin quizlet?
- 14 What is the most common adverse effect of the drug vancomycin when it is infused too rapidly?
- 15 Why must a client who is receiving aminoglycosides be kept well hydrated?
Which lab test is to be monitored while the client is on treatment with aminoglycosides?
Tests that reflect the health of the kidneys, such as a creatinine and estimated glomerular filtration rate (eGFR), are often ordered prior to the initiation of aminoglycoside therapy and then at intervals to monitor kidney function.
What labs should be monitored with gentamicin?
Gentamicin is cleared by the kidney and accumulates in renal tubular cells. Nephrotoxicity is most closely related to the length of time that trough levels are >2 μg/mL. Creatinine levels should be monitored every two to three days as an indicator of impending renal toxicity.
Which labs should be monitored before and during the antibiotic therapy?
Laboratory tests that can be helpful in guiding antimicrobial therapy include antimicrobial susceptibility testing, determination of bacterial beta-lactamase production, assay of serum inhibitory and bactericidal activity, and assay of specific antibiotic levels in serum.
Which condition would the nurse monitor for in a patient who is taking an aminoglycoside antibiotic quizlet?
When they are combined with an aminoglycoside they cause anticoagulant toxicity by inhibiting the action of vitamin K in the body. Therefore, the nurse should check for abnormal bleeding in a patient who is administered both amikacin and anticoagulants.
What drugs require therapeutic monitoring?
Therapeutic Drug Monitoring
|Immunosuppressants||Cyclosporine, tacrolimus, sirolimus, mycophenolate mofetil, azathioprine|
|Anti-cancer drugs||Methotrexate, all cytotoxic agents|
|Psychiatric drugs||Lithium, valproic acid, some antidepressants (imipramine, amitriptyline, nortriptyline, doxepin, desipramine)|
What are the factors controlling therapeutic drug monitoring?
There are numerous variables that influence the interpretation of drug concentration data: time, route and dose of drug given, time of blood sampling, handling and storage conditions, precision and accuracy of the analytical method, validity of pharmacokinetic models and assumptions, co-medications and, last but not
What trough level would be considered a normal concentration?
An acceptable trough is < 10 mg/mL. Peak levels are not necessary for patients being treated with a course of antibiotics without an identified organism. If obtained, an acceptable peak is 20 – 40 mg/mL and should be obtained 30 minutes after the infusion.
What are two serious side effects of gentamicin or tobramycin?
Let your child’s doctor or nurse know as soon as possible if your child has any of these side effects:
- loss of hearing.
- ringing or buzzing in the ears.
- feeling of fullness of the ears.
- increased thirst.
- needing to urinate more or less frequently than usual.
- skin rash or itchiness.
- unusual drowsiness, dizziness, or weakness.
What is a peak and trough level?
The trough level is the lowest concentration in the patient’s bloodstream, therefore, the specimen should be collected just prior to administration of the drug. The peak level is the highest concentration of a drug in the patient’s bloodstream.
Why do some drugs need to have their blood levels monitored?
These tests are used to monitor blood concentrations of particular drugs that have a narrow dose range in which the drug is effective but not toxic. In addition, some drugs require monitoring because the amount of drug administered does not correlate well with the amount of drug that reaches the bloodstream.
How do you do Therapeutic Drug Monitoring?
Clinicians routinely monitor drug pharmacodynamics by directly measuring the physiological indices of therapeutic responses, such as lipid concentrations, blood glucose, blood pressure, and clotting. For many drugs, either no measure of effect is readily available, or the method is insufficiently sensitive .
Which antibiotics require therapeutic monitoring?
Gentamicin, tobramycin and amikacin are the three antibiotics mostly subjected to TDM.
Which antibiotic is used in patients who have infections of the eyes ears or skin quizlet?
Because intravenous infusion of neomycin is associated with a high risk of ototoxicity and nephrotoxicity, the drug is reserved for use against infections of the eyes, ears, and skin and to suppress the bowel flora. Topical gentamicin and tobramycin are used to treat Gram-negative conjunctivitis.
What is the most common adverse effect of the drug vancomycin when it is infused too rapidly?
During or soon after rapid infusion of vancomycin, patients may develop anaphylactoid reactions, including hypotension (see Animal Pharmacology), wheezing, dyspnea, urticaria, or pruritus. Rapid infusion may also cause flushing of the upper body (“red neck”) or pain and muscle spasm of the chest and back.
Why must a client who is receiving aminoglycosides be kept well hydrated?
Why must a client who is receiving aminoglycosides be kept well hydrated? Hydration increases drug concentration in serum and body tissues. Hydration decreases drug concentration in serum and body tissues. Hydration stabilizes peak serum levels.