Question: Which Of The Following Can Result When Antibiotic Therapy Disrupts The Normal Microbiot?


What happens when antibiotic therapy disrupts the normal microbiota?

Based on clinical and epidemiological studies, it has been hypothesized that both the therapeutic use of antibiotics and the typical diets in industrialized countries may disrupt normal microbiota -mediated mechanisms of immunological tolerance in the mucosa, which also may result in an increase in allergic airway

Which of the following antibiotics disrupt cytoplasmic membrane function?

Disruption of the cytoplasmic membrane by the faulty proteins kills the bacterial cells. The aminoglycosides, which include drugs such as streptomycin, gentamicin, neomycin, and kanamycin, are potent broad-spectrum antibacterials.

Which of the following antifungals work by binding to ergosterol in membranes?

Polyene Antifungals The fungal cell membrane becomes leaky, resulting in movement of essential cellular contents, such as organic molecules and ions, out of the cell. Amphotericin B is an example of a polyene antifungal; it is selective for ergosterol and can be used as a broad spectrum drug administered intravenously.

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Which of the following antifungals works by preventing the synthesis of ergosterol?

6. Naftifine (Naftin) and terbinafine (Lamisil) are allylamines that block synthesis of ergosterol as does the topical thiocarbonate tolnaftate. They are used to treat dermatophyte infections.

Which general category of antibiotics are result in the inhibition of protein synthesis quizlet?

Aminoglycosides and tetracyclines are inhibitors of protein synthesis. Penicillins and cephalosporins inhibit nucleic acid synthesis. Sulfonamides inhibit the synthesis of essential metabolites. Lipopeptides inhibit cell wall synthesis.

Which drug is effective against Haemophilus influenzae infections?

An antibiotic, such as ceftriaxone, cefotaxime, or cefuroxime, is given. Other infections due to Haemophilus influenzae are treated with various antibiotics given by mouth. They include amoxicillin/clavulanate, azithromycin, cephalosporins, fluoroquinolones, and clarithromycin.

Why do antibiotics not work against viruses quizlet?

Viruses are not living and reproduce using their host cell’s metabolic pathways. Antibiotics do not affect the host cell’s metabolic processes and so the antibiotics are not effective against viruses.

What antibiotics inhibit protein synthesis?

Antibiotics can inhibit protein synthesis by targeting either the 30S subunit, examples of which include spectinomycin, tetracycline, and the aminoglycosides kanamycin and streptomycin, or to the 50S subunit, examples of which include clindamycin, chloramphenicol, linezolid, and the macrolides erythromycin,

What are the 5 mechanisms of action of antibiotics?

  • Five Basic Mechanisms of Antibiotic Action against Bacterial Cells:
  • Inhibition of Cell Wall Synthesis.
  • Inhibition of Protein Synthesis (Translation)
  • Alteration of Cell Membranes.
  • Inhibition of Nucleic Acid Synthesis.
  • Antimetabolite Activity.

What is the mode of action of azole antifungals?

The generally accepted mode of action of azoles is the inhibition of 14α-lanosterol demethylase, a key enzyme in ergosterol biosynthesis, resulting in depletion of ergosterol and accumulation of toxic 14α-methylated sterols in membranes of susceptible yeast species.

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What is the mode of action of most antifungal drugs?

The most common mode of action for antifungal drugs is the disruption of the cell membrane. Antifungals take advantage of small differences between fungi and humans in the biochemical pathways that synthesize sterols.

What are the classes of antifungal drugs?

The four main classes of antifungal drugs are the polyenes, azoles, allylamines and echinocandins.

What does ergosterol mean?

: a crystalline steroid alcohol C28H44O that occurs especially in yeast, molds, and ergot and is converted by ultraviolet irradiation ultimately into vitamin D2.

What are the nature and mode of action of antifungal agents?

The azole antifungal drugs act by inhibiting the synthesis of the sterol components of the fungal membrane. Azoles are predominantly fungistatic. They inhibit C-14 α-demethylase (a cytochrome P450 [CYP450] enzyme), thereby blocking the demethylation of lanosterol to ergosterol, the principal sterol of fungal membranes.

What drugs are Echinocandins?

Echinocandins are a group of semisynthetic, cyclic lipopeptides with an N-linked acyl lipid side chain. The drugs in the class are: caspofungin, micafungin and anidulafungin.

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