Question: What Is A Ketolide Antibiotic?


Is clindamycin a Ketolide?

Macrolides, Clindamycin, and Ketolides Ketolides are derived from erythromycin A, differing in having a replacement of the l-cladinose moiety that is present at position 3 in other 14-member macrolides with a ketone group. This is the only chemical modification necessary to classify a ketolide.

Which of the following is a ketolide antibiotic?

Telithromycin is a ketolide antibiotic and the only one in that group currently approved. Telithromycin has structural modifications in the macrolide ring that render it and other members of this group less likely to develop resistance against many gram-positive bacteria.

What are Ketolides used for?

Ketolides are used to treat community-acquired bacterial pneumonia. Other respiratory tract infections were removed as indications when it was recognized that use of telithromycin can result in hepatitis and liver failure.

Are Ketolides bactericidal?

Ketolides bind to the bacterial 50S ribosomal subunit and inhibit RNA-dependent protein synthesis. They are bacteriostatic at low concentrations and bactericidal at high concentration, so basically exhibit concentration dependent killing.

What medications are macrolides?

Five macrolide antibiotics are currently available for use in the United States: erythromycin, clarithromycin, azithromycin, fidaxomicin and telithromycin, the latter being a related ketolide.

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Is clindamycin an antibiotic?

Clindamycin is used to treat a wide variety of bacterial infections. It is an antibiotic that works by stopping the growth of bacteria.

Is chloramphenicol an antibiotic?

Chloramphenicol is an antibiotic. It’s mainly used to treat eye infections (such as conjunctivitis) and sometimes ear infections. Chloramphenicol comes as eye drops or eye ointment.

Is metronidazole an antibiotic?

Metronidazole is an antibiotic. It’s used to treat skin infections, rosacea and mouth infections (including infected gums and dental abscesses). It’s used in the treatment of conditions such as bacterial vaginosis and pelvic inflammatory disease.

What antibiotics are in the tetracycline family?

Although tetracyclines all work in the same way, there are differences between the four tetracyclines (demeclocycline, doxycycline, minocycline, and tetracycline ) that are available in the U.S. What are the differences between tetracyclines?

Generic name Brand name examples
tetracycline Ala-tet, Tetracap

How do quinolones work?

Mechanism of action Quinolones inhibit replication of bacterial DNA by blocking the ligase domain of bacterial DNA gyrase (topoisomerase II); some also inhibit topoisomerase IV. These enzymes relax DNA supercoils and enable DNA replication and repair (see Fig. 51.1). The effect of quinolones is bactericidal.

Is clarithromycin an antibiotic?

Clarithromycin is an antibiotic. It’s used to treat chest infections, such as pneumonia, skin problems such as cellulitis, and ear infections. It’s also used to get rid of Helicobacter pylori, a bacteria that can cause stomach ulcers.

What is the brand name for telithromycin?

BRAND NAME (S): Ketek. WARNING: Telithromycin should not be used in patients with myasthenia gravis.

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Where do macrolides come from?

Macrolides are a class of antibiotics derived from Saccharopolyspora erythraea (originally called Streptomyces erythreus), a type of soil-borne bacteria. Macrolides inhibit protein synthesis in bacteria by reversibly binding to the P site of the 50S unit of the ribosome.

What class of antibiotic is Linezolid?

Linezolid is a synthetic antibiotic belonging to a new class of antimicrobials called the oxazolidinones. Linezolid disrupts bacterial growth by inhibiting the initiation process of protein synthesis—a mechanism of action that is unique to this class of drugs.

Are quinolones and fluoroquinolones the same?

Quinolones are a type of antibiotic. Antibiotics kill or inhibit the growth of bacteria. There are five different quinolone classes. In addition, another class of antibiotic, called fluoroquinolones, were derived from quinolones by modifying their structure with fluorine.

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