Question: . “molecular Structure Reveals How The Antibiotic Streptomycin Wo?

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How does streptomycin work?

Streptomycin is an aminoglycoside. It works by blocking the ability of 30S ribosomal subunits to make proteins, which results in bacterial death. Albert Schatz first isolated streptomycin in 1943 from Streptomyces griseus.

How does streptomycin work to destroy bacteria?

Streptomycin kills bacteria by compromising the ribosome. Streptomycin is an effective antibiotic because its structure is similar to that of the anticodons that would usually bind to the ribosome. Streptomycin is significant because it was the first antibiotic that could treat tuberculosis.

How does streptomycin target prokaryotic ribosomes but not eukaryotic?

Antibiotics are simply chemicals that kill prokaryotic cells but do not harm eukaryotic cells. They are natural chemicals produced by fungi and bacteria that act to control their bacterial competitors. For example, streptomycin stops protein synthesis in prokaryotic cells by binding to their unusual ribosomes.

What infections does streptomycin treat?

What is streptomycin? Streptomycin is an antibiotic that is used to treat moderate to severe tuberculosis, pneumonia, E. coli, influenza, plague and other infections caused by certain bacteria.

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What type of antibiotic is streptomycin?

Streptomycin belongs to a class of drugs known as aminoglycoside antibiotics. It works by killing the organisms that cause the infection. This drug may also be used to treat other serious infections (e.g., Mycobacterium avium complex-MAC, tularemia, endocarditis, plague) along with other medications.

Why is streptomycin not used?

A history of clinically significant hypersensitivity to streptomycin is a contraindication to its use. Clinically significant hypersensitivity to other aminoglycosides may contraindicate the use of streptomycin because of the known cross-sensitivity of patients to drugs in this class.

Why is streptomycin not given intravenously?

However, the association of intravenous administration, high serum levels of the drug and an increase in side effects led to the decision to recommend intramuscular injection of streptomycin. This belief has remained until now and providers do not recommend intravenous administration of streptomycin.

Why streptomycin is no longer used?

Streptomycin was the first effective antituberculosis drug but is no longer a first-line drug as it has the disadvantage that it is not absorbed from the intestine and must therefore be given by intramuscular injection.

What bacteria is resistant to streptomycin?

More recently, mutations in rRNA genes have been found to be associated with in vivo acquired drug resistance in bacterial pathogens, e.g., in Mycobacterium tuberculosis resistant to streptomycin (10); most of the mutations found mapped to the 530 region of 16S rRNA (15, 27).

Is streptomycin an antifungal?

The parent of the streptomycin class It has a role as an antimicrobial agent, an antimicrobial drug, an antibacterial drug, a protein synthesis inhibitor, a bacterial metabolite and an antifungal agrochemical. It is an antibiotic antifungal drug, an antibiotic fungicide and a member of streptomycins.

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Is chloromycetin an antibiotic?

This medication is used to treat bacterial eye infections. Chloramphenicol is an antibiotic that works by stopping the growth of bacteria. This medication treats only bacterial eye infections.

Why do antibiotics target ribosomes?

The ribosome is a major bacterial target for antibiotics. Drugs inhibit ribosome function either by interfering in messenger RNA translation or by blocking the formation of peptide bonds at the peptidyl transferase centre. These effects are the consequence of the binding of drugs to the ribosomal subunits.

Is streptomycin a broad spectrum antibiotic?

Streptomycin possesses a broad spectrum of antibacterial activity. It is the first clinically effective drug used for treating tuberculosis.

What type of cell is a bacteria?

Prokaryotic cells (i.e., Bacteria and Archaea) are fundamentally different from the eukaryotic cells that constitute other forms of life. Prokaryotic cells are defined by a much simpler design than is found in eukaryotic cells.

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