Often asked: Which Antibiotic Inhibits Translation Initiation?


What antibiotic interferes with translation?

First, antibiotics with similar mode of action tend to exhibit additive drug interactions: In particular, there are purely additive interactions between capreomycin (CRY) and fusidic acid (FUS), which both inhibit translocation, and streptomycin (STR), which interferes with tRNA binding and also slightly lowers the

Which antibiotic inhibits the translation in eukaryotes?

Among the known inhibitors of eukaryotic translation is cycloheximide (CHX, 1), the most common laboratory reagent used to inhibit protein synthesis (Fig. 1). CHX has been shown to block the elongation phase of eukaryotic translation. It binds the ribosome and inhibits eEF2-mediated translocation2.

Which antibiotic does not inhibit translation in bacteria?

Lincomycin and clindamycin are specific inhibitors of peptidyl transferase, while macrolides do not directly inhibit the enzyme.

Which of the following antibiotics inhibit translation by blocking the elongation stage?

Chloramphenicol blocks the peptidyl transfer step of elongation on the 50S ribosomal subunit in both bacteria and mitochondria. Macrolides, clindamycin, and aminoglycosides have evidence of inhibition of ribosomal translocation. Streptogramins also cause premature release of the peptide chain.

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Which steps in translation are blocked by macrolides?

Macrolide antibiotics inhibit translation by binding in the ribosomal nascent peptide exit tunnel. It was believed that macrolides interfere with protein synthesis by obstructing the egress of nascent proteins.

Why do antibiotics not affect human cell translation?

Human cells do not make or need peptidoglycan. The result is a very fragile cell wall that bursts, killing the bacterium. No harm comes to the human host because penicillin does not inhibit any biochemical process that goes on within us. Bacteria can also be selectively eradicated by targeting their metabolic pathways.

Which antibiotic inhibits translation in both prokaryotes and eukaryotes?

Antibiotics That Block Translation. Puromycin acts on both prokaryotic and eukaryotic cells. It has a structure similar to that of the 3′ end of the aminoacyl-tRNA carrier of tyrosine or phenylalanine.

Which antibiotic inhibits translation in prokaryotes?

Macrolides, clindamycin and aminoglycosides (with all these three having other potential mechanisms of action as well), have evidence of inhibition of ribosomal translocation. Fusidic acid prevents the turnover of elongation factor G (EF-G) from the ribosome.

What antibiotics inhibit protein synthesis?

Antibiotics can inhibit protein synthesis by targeting either the 30S subunit, examples of which include spectinomycin, tetracycline, and the aminoglycosides kanamycin and streptomycin, or to the 50S subunit, examples of which include clindamycin, chloramphenicol, linezolid, and the macrolides erythromycin,

Why do antibiotics target protein synthesis?

Antibiotics that bind the A-site, such as the aminoglycosides, interfere with codon recognition and translocation. Peptide bond formation is inhibited when small molecules like oxazolidinones bind at the PTC. Finally, macrolides tend to block the growth of the amino acid chain at the peptide exit tunnel.

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What is broad spectrum antibiotics?

The term ” broad spectrum antibiotics ” was originally used to designate antibiotics that were effective against both gram-positive and gram-negative bacteria, in contrast to penicillin, which is effective chiefly against gram-positive organisms, and streptomycin, which is active primarily against gram-negative bacteria.

Which of the following is agents are narrow spectrum antibiotics?

Examples of narrow – spectrum antibiotics are the older penicillins (penG), the macrolides and vancomycin. Examples of broad – spectrum antibiotics are the aminoglycosides, the 2nd and 3rd generation cephalosporins, the quinolones and some synthetic penicillins.

Does ampicillin inhibit protein synthesis?

The role of protein synthesis in ampicillin -induced lysis of Escherichia coli was investigated. The inhibition of protein synthesis through amino acid deprivation resulted in the rapid development of ampicillin tolerance as a consequence of the stringent response, as previously reported.

Which of the following antibiotics inhibits folic acid synthesis?

5.2 Trimethoprim. TMP is a synthetic antibiotic that binds with the enzyme dihydrofolate reductase (DHFR) inhibiting the folic acid synthesis pathway (Brogden et al., 1982). It is widely used in the treatment of urinary tract infections and Pneumocystis jiroveci pneumonia.

What is bacterial protein synthesis?

The synthesis of proteins in bacteria is essentially a two-stage process involving transcription (the synthesis of a messenger RNA (mRNA) intermediate using one strand of the duplex DNA as the template) and translation (the decoding of the information in the mRNA into an ordered arrangement of amino acids to form a

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