- 1 Which drugs inhibits RNA and DNA synthesis?
- 2 What drugs inhibit RNA synthesis?
- 3 Which drug interferes with DNA synthesis?
- 4 Which of the following antibiotics work by blocking DNA replication?
- 5 What inhibits DNA synthesis?
- 6 What is the meaning of DNA synthesis?
- 7 What is the process of RNA synthesis?
- 8 Which antibiotic inhibits protein synthesis?
- 9 What classes of drugs inhibit nucleic acid synthesis?
- 10 What drug prevents DNA replication?
- 11 Is DNA a polymerase?
- 12 What are Okazaki fragments?
- 13 Do antibiotics target peptidoglycan synthesis?
- 14 How do antibiotics stop DNA synthesis?
- 15 What are the 5 mechanisms of action of antibiotics?
Which drugs inhibits RNA and DNA synthesis?
Drugs in this family, such as nalidixic acid, ciprofloxacin, and norfloxacin, work by inhibiting enzymes that are required for bacterial DNA synthesis. So, in contrast to the rifamycins, which inhibit transcription of DNA into RNA, the quinolones and fluoroquinolones inhibit DNA replication.
What drugs inhibit RNA synthesis?
Nucleic Acid Synthesis Inhibitors
|Rimantadine||An RNA synthesis inhibitor used to prevent influenza A infection.|
|Zidovudine||A dideoxynucleoside used in the treatment of HIV infection.|
|Foscarnet||An antiviral used to treat CMV, HIV, and HSV infections.|
Which drug interferes with DNA synthesis?
Quinolones are usually bactericidal in action and act by inhibiting DNA topoisomerase (ATP-hydrolyzing), a type II DNA topoisomerase commonly referred to as DNA -gyrase, in susceptible organisms.
Which of the following antibiotics work by blocking DNA replication?
Nalidixic acid selectively inhibits the activity of bacterial DNA gyrase, blocking DNA replication. Chemical modifications to the original quinolone backbone have resulted in the production of fluoroquinolones, like ciprofloxacin and levofloxacin, which also inhibit the activity of DNA gyrase.
What inhibits DNA synthesis?
Quinolones are a key group of antibiotics that interfere with DNA synthesis by inhibiting topoisomerase, most frequently topoisomerase II ( DNA gyrase), an enzyme involved in DNA replication.
What is the meaning of DNA synthesis?
Definition. DNA synthesis is the biological process by which a deoxyribonucleic acid ( DNA ) molecule is created. In the cell, each of the two strands of the DNA molecule acts as a template for the synthesis of a complementary strand.
What is the process of RNA synthesis?
The process of synthesizing RNA from the genetic information encoded by DNA is called transcription. The enzymes involved in transcription are called RNA polymerases. The b’ subunit binds the DNA while the b subunit binds the nucleotides that are to be joined together to form the RNA molecule.
Which antibiotic inhibits protein synthesis?
Antibiotics can inhibit protein synthesis by targeting either the 30S subunit, examples of which include spectinomycin, tetracycline, and the aminoglycosides kanamycin and streptomycin, or to the 50S subunit, examples of which include clindamycin, chloramphenicol, linezolid, and the macrolides erythromycin,
What classes of drugs inhibit nucleic acid synthesis?
There are two major classes: DNA inhibitors and RNA inhibitors.
What drug prevents DNA replication?
DNA Polymerase Inhibitors As noted above AraC or acyclovir derive there inhibitory effect from the termination of chain elongation that occurs after the nucleotide of the drug is incorporated into the elongating DNA strand causing structural changes that prevent further DNA elongation.
Is DNA a polymerase?
DNA polymerase is responsible for the process of DNA replication, during which a double-stranded DNA molecule is copied into two identical DNA molecules. Scientists have taken advantage of the power of DNA polymerase molecules to copy DNA molecules in test tubes via polymerase chain reaction, also known as PCR.
What are Okazaki fragments?
Okazaki fragments are short sequences of DNA nucleotides (approximately 150 to 200 base pairs long in eukaryotes) which are synthesized discontinuously and later linked together by the enzyme DNA ligase to create the lagging strand during DNA replication.
Do antibiotics target peptidoglycan synthesis?
Two types of antimicrobial drugs work by inhibiting or interfering with cell wall synthesis of the target bacteria. Antibiotics commonly target bacterial cell wall formation (of which peptidoglycan is an important component) because animal cells do not have cell walls.
How do antibiotics stop DNA synthesis?
a) Quinolone antibiotics interfere with changes in DNA supercoiling by binding to topoisomerase II or IV. This leads to the formation of double-stranded DNA breaks and cell death in either a protein synthesis dependent or protein synthesis independent fashion.
What are the 5 mechanisms of action of antibiotics?
- Five Basic Mechanisms of Antibiotic Action against Bacterial Cells:
- Inhibition of Cell Wall Synthesis.
- Inhibition of Protein Synthesis (Translation)
- Alteration of Cell Membranes.
- Inhibition of Nucleic Acid Synthesis.
- Antimetabolite Activity.