FAQ: Describe What Happens If An Antibiotic Inhibits Bactoprenol Function In A Growing Bacterial Cell?


What is the role of Bactoprenol during the bacterial cell wall synthesis?

Bactoprenol is thought to play a key role in the formation of cell walls in gram-positive bacteria by cycling peptidoglycan monomers through the plasma membrane and inserting these monomers at points of growth in the bacterial cell wall.

What antibiotic inhibits peptidoglycan synthesis?

β-Lactam antibiotics are bacteriocidal and act by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. Glycopeptide antibiotics include vancomycin, teicoplanin, telavancin, bleomycin, ramoplanin, and decaplanin.

What antibiotics inhibit bacterial cell wall synthesis?

Penicillins and cephalosporins are the major antibiotics that inhibit bacterial cell wall synthesis. They are called beta-lactams because of the unusual 4-member ring that is common to all their members.

What is the function of peptidoglycan in bacterial cells?

Peptidoglycan is the basic unit of the cell wall in bacteria, which confers mechanical rigidity to the cell, protects the cytoplasmic membrane and determines the cell form. In Gram-positive bacteria, a thick coat of peptidoglycan combined with teichoic acid constitutes the basic structure of the cell wall.

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Which bacteria has a thicker cell wall?

Gram positive bacteria possess a thick (20–80 nm) cell wall as outer shell of the cell. In contrast Gram negative bacteria have a relatively thin (<10 nm) layer of cell wall, but harbour an additional outer membrane with several pores and appendices.

Can bacterial cell walls consist largely of protein?

Cytoplasmic Structures Plasma Membrane: The bacterial plasma membrane is composed primarily of protein and phospholipid (about 3:1). It performs many functions, including transport, biosynthesis, and energy transduction.

What antibiotic inhibits protein synthesis?

Antibiotics can inhibit protein synthesis by targeting either the 30S subunit, examples of which include spectinomycin, tetracycline, and the aminoglycosides kanamycin and streptomycin, or to the 50S subunit, examples of which include clindamycin, chloramphenicol, linezolid, and the macrolides erythromycin,

What interferes with peptidoglycan synthesis?

Significant glycopeptide antibiotics include vancomycin, teicoplanin, telavancin, bleomycin, ramoplanin, and decaplanin. This class of drugs inhibit the synthesis of cell walls in susceptible microbes by inhibiting peptidoglycan synthesis.

Which of the following antibiotics inhibits protein synthesis?

These antibiotics include bacitracin, glycopeptides such as vancomycin, and β-lactam antibiotics. Macrolides such as azithromycin, lincosamides (clindamycin), linezolid, chloramphenicol, aminoglycosides such as tobramycin, mupirocin, and tetracycline all inhibit protein synthesis.

How do antibiotics destroy the bacterial cell membranes?

Many antibiotics, including penicillin, work by attacking the cell wall of bacteria. Specifically, the drugs prevent the bacteria from synthesizing a molecule in the cell wall called peptidoglycan, which provides the wall with the strength it needs to survive in the human body.

Why is cell wall synthesis a good target for antibiotics?

Because peptidoglycan is a critical cell structure, its assembly is the target of antibiotics such as β-lactams and glycopeptides (e.g., vancomycin). Modification of peptidoglycan synthesis is a response of resistant staphylococci to cell wall –active antibiotics (see “ Antibiotic Resistance”).

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What cellular structure do antibiotics typically target?

In principal, there are three main antibiotic targets in bacteria: The cell wall or membranes that surrounds the bacterial cell. The machineries that make the nucleic acids DNA and RNA. The machinery that produce proteins (the ribosome and associated proteins)

Is peptidoglycan in all bacteria?

Peptidoglycan (murein) is an essential and specific component of the bacterial cell wall found on the outside of the cytoplasmic membrane of almost all bacteria (Rogers et al., 1980; Park, 1996; Nanninga, 1998; Mengin-Lecreulx & Lemaitre, 2005).

What is the importance of peptidoglycan?

Peptidoglycan serves a structural role in the bacterial cell wall, giving structural strength, as well as counteracting the osmotic pressure of the cytoplasm. Peptidoglycan is also involved in binary fission during bacterial cell reproduction.

Do human cells have peptidoglycan?

Human cells do not make or need peptidoglycan. Penicillin, one of the first antibiotics to be used widely, prevents the final cross-linking step, or transpeptidation, in assembly of this macromolecule. The result is a very fragile cell wall that bursts, killing the bacterium.

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