Natamycin was initially the result of isolating the Streptomyces natalensis bacterium. However, experiments have also shown that it can be produced by other varieties including Streptomyces gilvosporeus, Streptomyces chattanoogensis and Streptomyces lydicus.
Several studies based on the biosynthesis process included in the gene groups of Streptomyces natalensis and Streptomyces chattanoogensis have proved that they are very similar to each other. However, it is the characteristics of the Streptomyces gilvosporeus genome that have mainly been defined.
This variety of Streptomyces – also known as F607 – is an industrial strain with high natamycin production that was developed from several mutagens. After an exhaustive observation of its DNA sequence, it has been determined that it is very similar to the clusters of Streptomyces natalensis, Streptomyces chattanoogensis and Streptomyces lydicus mentioned above.
After demonstrating the genomic similarity between Streptomyces gilvosporeus and the other varieties, the understanding of how the molecular mechanisms involved biosynthesis and its regulation function will lead to new studies based on genetic engineering, which will, in turn, enable the industrial production of natamycin to be improved.