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The effect of propanol on natamycin

Some studies have shown that the production of natamycin may be affected by short chain fatty acids and alcohols. However, the addition of propanol has proven to be a much more effective additive, which can increase production rates of natamycin by up to 17 %.

Furthermore, metabolite analysis shows an increase in amino acid and acetyl-CoA concentrations, while concentrations of organic acids produced during the cycles of tricarboxylic acids are reduced.

This means that adding propanol is an effective strategy for enhancing the performance of natamycin, by regulating the metabolic ganglia that form part of this antifungal agent and its precursor group.